Which device is characterized by being a glove box that operates under negative pressure and is used for hazardous drug preparation?

• A. Compounding aseptic isolator (CAI)
• B. Laminar airflow workbench
• C. Compounding aseptic containment isolators (CACI)
• D. HEPA filter

Answer: (C)

The device characterized as a glove box that operates under negative pressure for hazardous drug preparation is known as a Compounding Aseptic Containment Isolator (CACI). This type of isolator provides a controlled environment that ensures the safety of the personnel handling hazardous drugs by preventing exposure to these substances. The negative pressure within the isolator is critical as it not only protects the healthcare workers from harmful fumes and particles but also contains any hazardous materials within the chamber, minimizing the risk of contamination in the surrounding area.

Unlike a Compounding Aseptic Isolator (CAI), which is designed for non-hazardous preparations and maintains positive pressure to ensure sterility, a CACI specifically caters to hazardous compounding needs. This distinction is vital for maintaining safety standards in environments where potent medications are prepared and handled. The CACI is equipped with appropriate ventilation systems to filter the air effectively, ensuring that any potential contamination or exposure is mitigated.

While a laminar airflow workbench facilitates sterile practices through airflow dynamics, it does not provide the same level of containment necessary for hazardous drugs. A HEPA filter, although critical in maintaining air quality, is merely one component of the systems used in isolators and does not function as a standalone device for drug